KIT | KIT-Bibliothek | Impressum | Datenschutz

The transcriptional co-activator function of the LIM-domain protein nTrip6

Diefenbacher, Markus Elmar

Abstract:

An emerging class of proteins involved in the regulation of transcription are bridging factors. These proteins do not harbour any known co-activator function or domain, but are recruited to the promoter via a direct interaction with transcription factors. In this work I showed that nTrip6 acts as a selective co-activator for a subset of AP-1 dimers. Moreover, the interaction of AP-1 dimers with nTrip6 determines the ability of GR to transrepress these AP-1 dimers by tethering GR to the promoter.


Volltext §
DOI: 10.5445/IR/1000013322
Cover der Publikation
Zugehörige Institution(en) am KIT Fakultät für Chemie und Biowissenschaften (CHEM-BIO)
Publikationstyp Hochschulschrift
Publikationsjahr 2009
Sprache Englisch
Identifikator urn:nbn:de:swb:90-133225
KITopen-ID: 1000013322
Verlag Universität Karlsruhe (TH)
Art der Arbeit Dissertation
Fakultät Fakultät für Chemie und Biowissenschaften (CHEM-BIO)
Prüfungsdaten 12.02.2009
Schlagwörter Trip6, nTrip6, LIM-domain proteins, dimerisation, coactivator, AP-1, Jun, Fos, GR, Glucocorticoid receptor, gene array cell line, BiFC, JNK, MAPK
Referent/Betreuer Cato, A.
KIT – Die Forschungsuniversität in der Helmholtz-Gemeinschaft
KITopen Landing Page