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The RecQ gene family in plants

Hartung, F.; Puchta, H.

Abstract:
structure and function. They are 30–50 DNA helicases resolving different recombinogenic DNA structures. The RecQ helicases are key factors in a number of DNA repair and recombination pathways involved in the maintenance of genome integrity. In eukaryotes the number of RecQ genes and the structure of RecQ proteins vary strongly between organisms. Therefore, they have been named RecQ-like genes. Knockouts of several RecQ-like genes cause severe diseases in animals or harmful cellular phenotypes in yeast. Until now the largest number of RecQ-like genes per organism has been found in plants. Arabidopsis and rice possess seven different RecQ-like genes each. In the almost completely sequenced genome of the moss Physcomitrella patens at least five RecQ-like genes are present. One of the major present and future research aims is to define putative plant-specific functions and to assign their roles in DNA repair and recombination pathways in relation to RecQ genes from other eukaryotes. Regarding their intron positions, the structures of six RecQ-like genes of dicots and monocots are virtually identical indicating a conservation over a time scale of 150 million years. ... mehr

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Postprint §
DOI: 10.5445/IR/1000016580
Veröffentlicht am 08.04.2020
Originalveröffentlichung
DOI: 10.1016/j.jplph.2005.10.013
Cover der Publikation
Zugehörige Institution(en) am KIT Botanisches Institut und Botanischer Garten (BOTANIK)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2006
Sprache Englisch
Identifikator ISSN: 0176-1617, 1618-1328
KITopen-ID: 1000016580
Erschienen in Journal of plant physiology
Band 163
Heft 3
Seiten 287-296
Schlagwörter DNA repair; Holliday junction; Recombination; RecQ helicases
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