Reversible Addition-Fragmentation Chain Transfer-Hetero Diels-Alder (RAFT-HDA) Chemistry as an Efficient Conjugation Technique for Macromolecular Surface Engineering

In the current study - to achieve the modification of solid substrates in an efficient fashion - the next generation of RAFT agents capable of rapidly undergoing HDA reactions under ambient conditions and in the absence catalyst were synthesized. In addition, a range of highly innovative protocols for the orthogonal modification of variety solid substrates were established. The microspheres were also studied to obtain information about the amount of accessible active sites and grafting densities.