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Involvement of Tspan8 in exosome assembly and target cell selection

Rana, Sanyukta

Abstract:
Exosomes are the most important intercellular communicators. Tetraspanins/their complexes are suggested to be important in exosomal target cell selection. I showed: changes in Tetraspanin8 associations created from internalization persist upto exosomes and, differences in tetraspanin-complexes on exosomes allow for target cell selectivity.Based on the tetraspanin-complex on exosomes, predictions on potential target cells might be possible, allowing tailored exosome generation for drug delivery.

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Volltext §
DOI: 10.5445/IR/1000021823
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Zugehörige Institution(en) am KIT Institut für Genetik (IGEN)
Publikationstyp Hochschulschrift
Jahr 2010
Sprache Englisch
Identifikator urn:nbn:de:swb:90-218237
KITopen-ID: 1000021823
Verlag KIT, Karlsruhe
Abschlussart Dissertation
Fakultät Fakultät für Chemie und Biowissenschaften (CHEM-BIO)
Institut Institut für Genetik (IGEN)
Prüfungsdaten 15.12.2010
Referent/Betreuer Prof. M. Zöller
Schlagworte Tetraspanin8, Intersectin-2, Exosomes, target cell selcetion
KIT – Die Forschungsuniversität in der Helmholtz-Gemeinschaft
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