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DOI: 10.5445/IR/1000021823

Involvement of Tspan8 in exosome assembly and target cell selection

Rana, Sanyukta

Abstract:
Exosomes are the most important intercellular communicators. Tetraspanins/their complexes are suggested to be important in exosomal target cell selection. I showed: changes in Tetraspanin8 associations created from internalization persist upto exosomes and, differences in tetraspanin-complexes on exosomes allow for target cell selectivity.Based on the tetraspanin-complex on exosomes, predictions on potential target cells might be possible, allowing tailored exosome generation for drug delivery.


Zugehörige Institution(en) am KIT Institut für Genetik (IGEN)
Publikationstyp Hochschulschrift
Jahr 2010
Sprache Englisch
Identifikator URN: urn:nbn:de:swb:90-218237
KITopen-ID: 1000021823
Verlag Karlsruhe
Abschlussart Dissertation
Fakultät Fakultät für Chemie und Biowissenschaften (CHEM-BIO)
Institut Institut für Genetik (IGEN)
Prüfungsdaten 15.12.2010
Referent/Betreuer Prof. M. Zöller
Schlagworte Tetraspanin8, Intersectin-2, Exosomes, target cell selcetion
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