CD44 as a Hematopoietic stem cell marker
Abstract:
CD44 expression on hematopoietic stem cells (HSC) has been shown to be required for homing into the osteogenic niche. CD44 expression in HSC and bone marrow stroma contribute to the maintenance of quiescence and apoptosis resistance. A blockade of CD44 retarded growth and promoted apoptosis of leukemic cells via mitochondrial depolarization that is accompanied by caspase-9 cleavage. Apoptosis is initiated by activation of CD44 associated phosphatase 2A and proceeds via ERK1/2 dephosphorylation.
| Zugehörige Institution(en) am KIT | Institut für Toxikologie und Genetik (ITG) |
| Publikationstyp | Hochschulschrift |
| Publikationsjahr | 2011 |
| Sprache | Englisch |
| Identifikator | urn:nbn:de:swb:90-229564 KITopen-ID: 1000022956 |
| Verlag | Karlsruher Institut für Technologie (KIT) |
| Art der Arbeit | Dissertation |
| Fakultät | Fakultät für Chemie und Biowissenschaften (CHEM-BIO) |
| Institut | Institut für Toxikologie und Genetik (ITG) |
| Prüfungsdaten | 11.04.2011 |
| Schlagwörter | CD44, Hematopoietic stem cell, Apoptosis, Quiescence, Mitochondrial depolarization |
| Referent/Betreuer | Zöller, M. |