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URN: urn:nbn:de:swb:90-247534

Simulation of haemodynamic flow in head and neck chemotherapy

Rhode, S.

In recent years, intra arterial chemotherapy has become an important component in head and neck cancer treatment. However, therapy success can vary significantly and consistent treatment guidelines are missing.

The purpose of this study was to create a computer simulation of the chemical agent injection in the head and neck arteries to investigate the distribution and concentration of the chemical. This is of great interest for medical scientists and vital for prognosis. Realistic three dimensional patient specific geometry was created from image scan data. Engineering principles such as conservation of mass and momentum, turbulence models and a multiphase model were applied in a computational fluid dynamics (CFD) software.

At first, a steady cause and effect study with various turbulence and material models was made without the chemical component. It was discovered, that a non-\Newtonian material model is compulsory for blood. The shear stress transport k-w turbulence model is appropriate for the whole velocity range and of superior robustness.

These conclusions were used in the following two-component transient simulation ... mehr

Zugehörige Institution(en) am KIT Institut für Fahrzeugsystemtechnik (FAST)
Publikationstyp Hochschulschrift
Jahr 2011
Sprache Englisch
Identifikator KITopen ID: 1000024753
Umfang 102, XIII S.
Abschlussart Abschlussarbeit - Master
Bemerkung zur Veröffentlichung University of Glasgow & University of Applied Sciences Karlsruhe
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