KIT | KIT-Bibliothek | Impressum | Datenschutz
Open Access Logo
§
Volltext
URN: urn:nbn:de:swb:90-248120

Impact of Mdm2-p53 on the proteasome assembly and disassembly Role of the ubiquitination of some 19S subunits

Letienne, Justine

Abstract:
The ubiquitin proteasome system is a fundamental actor for the proteolysis of cellular proteins. My results demonstrated that the E3 ligase Mdm2 and its substrate p53 might be implied in the formation of the fully-assembled proteasome. Mdm2 promotes also the ubiquitination of some 19S subunits of the proteasome via a non-conventional chain and it is not a signal for self-degradation. Moreover, this ubiqitination seemed to play a role in the formation of the proteasome.


Zugehörige Institution(en) am KIT Institut für Toxikologie und Genetik (ITG)
Publikationstyp Hochschulschrift
Jahr 2011
Sprache Englisch
Identifikator KITopen ID: 1000024812
Verlag Karlsruhe
Abschlussart Dissertation
Fakultät Fakultät für Chemie und Biowissenschaften (CHEM-BIO)
Institut Institut für Toxikologie und Genetik (ITG)
Prüfungsdaten 18.10.2011
Referent/Betreuer PD Dr. C. Blattner
Schlagworte E3 liagase, Mdm2, p53, ubiquitin, 19S and 26S proteasomes
KIT – Die Forschungsuniversität in der Helmholtz-Gemeinschaft KITopen Landing Page