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URN: urn:nbn:de:swb:90-251705

Metastasis-associated C4.4A acts as a linker between membrane proteases and alpha6beta4

Ngora, Honoré

C4.4A is a metastasis-associated membrane proteins. Its expression is very restricted on normal tissue, but strongly upregulated during wound healing and progression in some tumors. The function of the molecule still remaining elusive, I aimed to shed some light on its transcriptional regulation and possible functions. Although C4.4A transcription is not promoted by HIF-1alpha, increase C4.4A expression under hypoxia supports motility, invasiveness and apoptosis resistance.

Zugehörige Institution(en) am KIT Zoologisches Institut (ZOO)
Publikationstyp Hochschulschrift
Jahr 2011
Sprache Englisch
Identifikator KITopen ID: 1000025170
Verlag Karlsruhe
Abschlussart Dissertation
Fakultät Fakultät für Chemie und Biowissenschaften (CHEM-BIO)
Institut Zoologisches Institut (ZOO)
Prüfungsdaten 17.10.2011
Referent/Betreuer Prof. D. Wedlich
Schlagworte Cancer, C4.4A, metastasis, membrane proteases, hypoxia
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