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Computational Biomechanics and Experimental Validation of Vessel Deformation based on 4D-CT Imaging of the Porcine Aorta

Hazer, D.; Finol, E.A.; Kostrzewa, M.; Kopaigorenko, M.; Richter, G.M.; Dillmann, R.

Abstract:
Cardiovascular disease results from pathological biomechanical conditions and fatigue of the vessel wall. Image-based computational modeling provides a physical and realistic insight into the patient-specific biomechanics and enables accurate predictive simulations of development, growth and failure of cardiovascular disease. An experimental validation is necessary for the evaluation and the clinical implementation of such computational models. In the present study, we have implemented dynamic Computed-Tomography (4D-CT) imaging and catheter-based in vivo measured pressures to numerically simulate and experimentally evaluate the biomechanics of the porcine aorta. The computations are based on the Finite Element Method (FEM) and simulate the arterial wall response to the transient pressure-based boundary condition. They are evaluated by comparing the numerically predicted wall deformation and that calculated from the acquired 4D-CT data. The dynamic motion of the vessel is quantified by means of the hydraulic diameter, analyzing sequences at 5% increments over the cardiac cycle. Our results show that accurate biomechanical modeling i ... mehr


Zugehörige Institution(en) am KIT Institut für Anthropomatik (IFA)
Publikationstyp Proceedingsbeitrag
Jahr 2009
Sprache Englisch
Identifikator KITopen-ID: 1000027064
Erschienen in Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging, Lake Buena Vista, FL, USA, 8 - 10 February 2009. Ed.: X. Hu
Verlag SPIE, Bellingham (Wash.)
Seiten Article ID 72621F
Serie Proceedings of SPIE ; 7262
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