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URN: urn:nbn:de:swb:90-321502

Novel Chemical Approach for the Site Selective Generation of Complex Self-Assembled Virus Derivatives

Azucena Serrano, Carlos Arturo

Abstract:
Main goal is to develop a method allowing an efficient and site-selective immobilization of Tobacco mosaic virus (TMV)-RNA on oxidic and polymeric surfaces using a bottom-up self-assembly strategy. Two new chemical approaches are introduced as linkers for DNA-ligands: Aldehyde converted alkoxysilane and in-house synthesized isothiocyanate (ITC) alkoxysilane. Substrates were characterized by X-ray photon spectroscopy (XPS), atomic force microscopy (AFM), contact angle (CA) and optical microscopy.


Zugehörige Institution(en) am KIT Institut für Funktionelle Grenzflächen (IFG)
Publikationstyp Hochschulschrift
Jahr 2012
Sprache Englisch
Identifikator URN: urn:nbn:de:swb:90-321502
KITopen ID: 1000032150
Verlag Karlsruhe
Abschlussart Dissertation
Fakultät Fakultät für Chemieingenieurwesen und Verfahrenstechnik (CIW)
Institut Institut für Funktionelle Grenzflächen (IFG)
Prüfungsdaten 05.12.2012
Referent/Betreuer Prof. M. Franzreb
Schlagworte Isothiocyanate, Tobacco Mosaic Virus, Silane, Surface Chemistry, Bottom-up Self-assembly, Self-assembled monolayers, Atomic Force Microscope
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