Novel Chemical Approach for the Site Selective Generation of Complex Self-Assembled Virus Derivatives

Main goal is to develop a method allowing an efficient and site-selective immobilization of Tobacco mosaic virus (TMV)-RNA on oxidic and polymeric surfaces using a bottom-up self-assembly strategy. Two new chemical approaches are introduced as linkers for DNA-ligands: Aldehyde converted alkoxysilane and in-house synthesized isothiocyanate (ITC) alkoxysilane. Substrates were characterized by X-ray photon spectroscopy (XPS), atomic force microscopy (AFM), contact angle (CA) and optical microscopy.