KIT | KIT-Bibliothek | Impressum

Towards a modified hydantoinase process for the chemoenzymatic production of chiral beta-amino acids - Substrate synthesis, screening, and characterization of novel biocatalysts

Engel, Ulrike

Abstract:
The aim of this thesis was to examine the applicability of a modified hydantoinase process to the production of chiral aromatic beta-amino acids. The hydantoinase process employs up to three enzymes for the dynamic kinetic resolution of 5beta-monosubstituted hydantoins via N-carbamoyl-beta-amino acids to beta-amino acids: a hydantoin racemase, a hydantoinase and a carbamoylase. It had to be studied whether these enzymes also show activity towards dihydropyrimidines and N-carbamoyl-beta-amino acids.


Zugehörige Institution(en) am KIT Institut für Bio- und Lebensmitteltechnik (BLT)
Publikationstyp Hochschulschrift
Jahr 2012
Sprache Englisch
Identifikator URN: urn:nbn:de:swb:90-337449
KITopen ID: 1000033744
Verlag Karlsruhe
Abschlussart Dissertation
Fakultät Fakultät für Chemieingenieurwesen und Verfahrenstechnik (CIW)
Institut Institut für Bio- und Lebensmitteltechnik (BLT)
Prüfungsdaten 19.10.2012
Referent/Betreuer Prof. C. Syldatk
Schlagworte hydantoinase, carbamoylase, hydantoinase-process, beta-amino acid
KIT – Die Forschungsuniversität in der Helmholtz-Gemeinschaft KITopen Landing Page