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Towards a modified hydantoinase process for the chemoenzymatic production of chiral beta-amino acids - Substrate synthesis, screening, and characterization of novel biocatalysts

Engel, Ulrike

Abstract:
The aim of this thesis was to examine the applicability of a modified hydantoinase process to the production of chiral aromatic beta-amino acids. The hydantoinase process employs up to three enzymes for the dynamic kinetic resolution of 5beta-monosubstituted hydantoins via N-carbamoyl-beta-amino acids to beta-amino acids: a hydantoin racemase, a hydantoinase and a carbamoylase. It had to be studied whether these enzymes also show activity towards dihydropyrimidines and N-carbamoyl-beta-amino acids.

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Volltext §
DOI: 10.5445/IR/1000033744
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Bio- und Lebensmitteltechnik (BLT)
Publikationstyp Hochschulschrift
Publikationsjahr 2012
Sprache Englisch
Identifikator urn:nbn:de:swb:90-337449
KITopen-ID: 1000033744
Verlag KIT, Karlsruhe
Art der Arbeit Dissertation
Fakultät Fakultät für Chemieingenieurwesen und Verfahrenstechnik (CIW)
Institut Institut für Bio- und Lebensmitteltechnik (BLT)
Prüfungsdaten 19.10.2012
Referent/Betreuer Prof. C. Syldatk
Schlagwörter hydantoinase, carbamoylase, hydantoinase-process, beta-amino acid
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