Synthesis of isotope labelled and photoactivatable N-acyl-L-homoserine lactones - inter kingdom signalling molecules

N-Acyl-L-homoserine lactones (AHLs) are signalling molecules. They enable bacteria to communicate with their eukaryotic host cells via inter-kingdom signalling. Very little is known about a mechanisms of such a interaction. Therefore isotope labelled and photoactivatable AHLs were synthesized in an effort to detect the cellular distribution and orientation of AHLs within the cell and find potential receptor of inter-kingdom signalling.