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On the Temporal Characteristics of Performance Variability in Attention Deficit Hyperactivity Disorder (ADHD)

Feige, B.; Biscaldi, M.; Saville, C.; Kluckert, C.; Bender, S.; Ebner-Priemer, U.W.; Hennighausen, K.; Rauh, R.; Fleischhaker, C.; Klein, C.

Increased intra-subject variability of reaction times (ISV-RT) is one of the most consistent findings in attention-deficit/hyperactivity disorder (ADHD). Although the nature of this phenomenon is still unclear, it has been hypothesised to reflect interference from the Default Mode Network (DMN). So far, ISV-RT has been operationally defined either as a frequency spectrum of the underlying RT time series, or as a measure of dispersion of the RT scores distribution. Here, we use a novel RT analysis framework to link these hitherto unconnected facets of ISV-RT by determining the sensitivity of different measures of RT dispersion to the frequency content of the underlying RT time series. N=27 patients with ADHD and N=26 healthy controls performed several visual N-back tasks. Different measures of RT dispersion were repeatedly modelled after individual frequency bands of the underlying RT time series had been either extracted or suppressed using frequency-domain filtering. We found that the intra-subject standard deviation of RT preserves the “1/f noise” characteristic typical of human RT data. Furthermore and most importantly, we found that the ex-Gaussian parameter τ is rather exclusively sensitive to frequencies below 0.025 Hz in the underlying RT time series and that the particularly slow RTs, which nourish τ, occur regularly as part of an quasi-periodic, ultra-slow RT fluctuation. ... mehr

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Verlagsausgabe §
DOI: 10.5445/IR/1000036776
Veröffentlicht am 26.09.2018
DOI: 10.1371/journal.pone.0069674
Zitationen: 32
Web of Science
Zitationen: 28
Zitationen: 29
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Sport und Sportwissenschaft (IfSS)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2013
Sprache Englisch
Identifikator ISSN: 1932-6203
KITopen-ID: 1000036776
Erschienen in PLoS one
Verlag Public Library of Science (PLoS)
Band 8
Heft 10
Seiten e69674
Nachgewiesen in Dimensions
Web of Science
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