Hsc70 mediated endocytosis regulates Fgf signaling in early zebrafish development

Tightly controlled concentration gradients of morphogens provide positional information and regulate tissue differentiation and morphogenesis in multi-cellular organisms. How morphogen gradients are formed and maintained remains debated. In this study I show that fibroblast growth factor 8 (Fgf8) morphogen gradients in zebrafish embryos are established and maintained by two essential mechanisms, the signaling strength and activity.