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URN: urn:nbn:de:swb:90-399169

Correlative Nanoscale 3D Imaging of Structure and Composition in Extended Objects

Xu, Feng; Helfen, Lukas; Suhonen, Heikki; Elgrabli, Dan; Bayat, Sam; Reischig, Peter; Baumbach, Tilo; Cloetens, Peter

Structure and composition at the nanoscale determine the behavior of biological systems and engineered materials. The drive to understand and control this behavior has placed strong demands on developing methods for high resolution imaging. In general, the improvement of three-dimensional (3D) resolution is accomplished by tightening constraints: reduced manageable specimen sizes, decreasing analyzable volumes, degrading contrasts, and increasing sample preparation efforts. Aiming to overcome these limitations, we present a non-destructive and multiple-contrast imaging technique, using principles of X-ray laminography, thus generalizing tomography towards laterally extended objects. We retain advantages that are usually restricted to 2D microscopic imaging, such as scanning of large areas and subsequent zooming-in towards a region of interest at the highest possible resolution. Our technique permits correlating the 3D structure and the elemental distribution yielding a high sensitivity to variations of the electron density via coherent imaging and to local trace element quantification through X-ray fluorescence. We demonstrate the m ... mehr

Zugehörige Institution(en) am KIT Institut für Synchrotronstrahlung (ISS)
Laboratorium für Applikationen der Synchrotronstrahlung (LAS)
Publikationstyp Zeitschriftenaufsatz
Jahr 2012
Sprache Englisch
Identifikator ISSN: 1932-6203
KITopen ID: 1000039916
HGF-Programm 55.52.10; LK 01
Erschienen in PLoS ONE
Band 7
Heft 11
Seiten e50124/1-6
Bemerkung zur Veröffentlichung Gefördert durch den KIT-Publikationsfonds
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