Der Mechanismus der Kontaktinhibition während der Migration von cranialen Neuralleistenzellen in Xenopus laevis
Abstract:
Collective cell migration is an essential feature both in embryonic development and cancer progression. Interestingly, local cell-cell interactions seem to be the key force for directionality. Cells can change their migration direction by a repulsive cell response called contact inhibition of locomotion (CIL). Here, we demonstrate that Xenopus cadherin-11 (Xcad-11) mediated cell-cell adhesion is necessary in CIL for directional and collective migration.
| Zugehörige Institution(en) am KIT | Zoologisches Institut (ZOO) |
| Publikationstyp | Hochschulschrift |
| Publikationsjahr | 2018 |
| Sprache | Deutsch |
| Identifikator | urn:nbn:de:swb:90-419075 KITopen-ID: 1000041907 |
| Verlag | Karlsruher Institut für Technologie (KIT) |
| Umfang | VI, 122 S. |
| Art der Arbeit | Dissertation |
| Fakultät | Fakultät für Chemie und Biowissenschaften (CHEM-BIO) |
| Institut | Zoologisches Institut (ZOO) |
| Prüfungsdatum | 18.07.2014 |
| Schlagwörter | Neuralleistenzellen, PCP-Signalweg, Kontaktinhibition, Kollektive Migration, Cadherin-11 |
| Referent/Betreuer | Wedlich, D. |