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URN: urn:nbn:de:swb:90-419159
DOI: 10.1155/2014/930308
Zitationen: 7
Web of Science
Zitationen: 7

Developmental stage-specific regulation of the circadian Clock by Temperature in Zebrafish

Lahiri, K.; Froehlich, N.; Heyd, A.; Foulkes, N.S.; Vallone, D.

The circadian clock enables animals to adapt their physiology and behaviour in anticipation of the day-night cycle. Light and temperature represent two key environmental timing cues (zeitgebers) able to reset this mechanism and so maintain its synchronization with the environmental cycle. One key challenge is to unravel how the regulation of the clock by zeitgebers matures during early development. The zebrafish is an ideal model for studying circadian clock ontogeny since the process of development occurs ex utero in an optically transparent chorion and many tools are available for genetic analysis. However, the role played by temperature in regulating the clock during zebrafish development is poorly understood. Here, we have established a clock-regulated luciferase reporter transgenic zebrafish line (Tg (−3.1) per1b::luc) to study the effects of temperature on clock entrainment. We reveal that under complete darkness, from an early developmental stage onwards (48 to 72 hpf), exposure to temperature cycles is a prerequisite for the establishment of self-sustaining rhythms of zfper1b, zfaanat2, and zfirbp expression and also for cir ... mehr

Zugehörige Institution(en) am KIT Institut für Toxikologie und Genetik (ITG)
Publikationstyp Zeitschriftenaufsatz
Jahr 2014
Sprache Englisch
Identifikator ISSN: 2314-6133
KITopen ID: 1000041915
HGF-Programm 47.01.01; LK 01
Erschienen in BioMed Research International
Band 2014
Seiten 930308
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