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A multiple endpoint approach to predict the hepatotoxicity of pharmaceuticals in vitro

Truisi, Germaine Loredana

Abstract:
A new approach was evaluated to predict the hepatotoxic potential of pharmaceuticals. For this purpose, primary rat and human hepatocytes cultured in an optimised sandwich configuration were used; thus, allowing the long-term, repeat-dosing of drugs. The strategy based on the evaluation of multiple endpoints, including cytotoxicity, biokinetic profiling, transcriptomics and proteomics. Pharmaceuticals with known toxicities and pharmacokinetic properties were used as model compounds.

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Volltext §
DOI: 10.5445/IR/1000042223
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Angewandte Biowissenschaften (IAB)
Publikationstyp Hochschulschrift
Publikationsjahr 2014
Sprache Englisch
Identifikator urn:nbn:de:swb:90-422237
KITopen-ID: 1000042223
Verlag KIT, Karlsruhe
Art der Arbeit Dissertation
Fakultät Fakultät für Chemie und Biowissenschaften (CHEM-BIO)
Institut Institut für Angewandte Biowissenschaften (IAB)
Prüfungsdaten 18.07.2014
Referent/Betreuer PD S. O. Müller
Schlagwörter Hepatotoxicity, in vitro, biokinetic, toxicogenomics
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