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All-Atom Modeling of Protein Folding and Aggregation

Wolf, Moritz


Theoretical investigations of biorelevant processes in the life-science research require highly optimized simulation methods. Therefore, massively parallel Monte Carlo algorithms, namely MTM, were successfully developed and applied to the field of reversible protein folding allowing the thermodynamic characterization of proteins on an atomistic level. Further, the formation process of trans-membrane pores in the TatA system could be elucidated and the structure of the complex could be predicted.

Volltext §
DOI: 10.5445/IR/1000043285
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Nanotechnologie (INT)
Publikationstyp Hochschulschrift
Publikationsjahr 2013
Sprache Englisch
Identifikator urn:nbn:de:swb:90-432853
KITopen-ID: 1000043285
HGF-Programm 43.11.03 (POF II, LK 01) Molecular building blocks
Verlag Karlsruher Institut für Technologie (KIT)
Art der Arbeit Dissertation
Fakultät Fakultät für Physik (PHYSIK)
Institut Institut für Nanotechnologie (INT)
Prüfungsdaten 22.11.2013
Prüfungsdatum 22.11.2013
Schlagwörter Reversible protein folding, MTM, Twin arginine translocase, TatA, SIMONA
Referent/Betreuer Wenzel, W.
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