KIT | KIT-Bibliothek | Impressum | Datenschutz

Pax6 regulates the formation of the habenular nuclei by controlling the temporospatial expression of Shh in the diencephalon in vertebrates

Chatterjee, M.; Guo, Q.; Weber, S. 1; Scholpp, S. 1; Li, J. Y. H.
1 Institut für Toxikologie und Genetik (ITG), Karlsruher Institut für Technologie (KIT)

Abstract:

Background

The habenula and the thalamus are two critical nodes in the forebrain circuitry and they connect the midbrain and the cerebral cortex in vertebrates. The habenula is derived from the epithalamus and rests dorsally to the thalamus. Both epithalamus and thalamus arise from a single diencephalon segment called prosomere (p)2. Shh is expressed in the ventral midline of the neural tube and in the mid-diencephalic organizer (MDO) at the zona limitans intrathalamica between thalamus and prethalamus. Acting as a morphogen, Shh plays an important role in regulating cell proliferation and survival in the diencephalon and thalamic patterning. The molecular regulation of the MDO Shh expression and the potential role of Shh in development of the habenula remain largely unclear.

Results

We show that deleting paired-box and homeobox-containing gene Pax6 results in precocious and expanded expression of Shh in the prospective MDO in fish and mice, whereas gain-of-function of pax6 inhibits MDO shh expression in fish. Using gene expression and genetic fate mapping, we have characterized the expression of molecular markers that demarcate the progenitors and precursors of habenular neurons. ... mehr


Volltext §
DOI: 10.5445/IR/1000046396
Originalveröffentlichung
DOI: 10.1186/1741-7007-12-13
Scopus
Zitationen: 29
Web of Science
Zitationen: 26
Dimensions
Zitationen: 31
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Toxikologie und Genetik (ITG)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2014
Sprache Englisch
Identifikator ISSN: 1741-7007
urn:nbn:de:swb:90-463964
KITopen-ID: 1000046396
HGF-Programm 47.01.01 (POF II, LK 01) Biologische Schlüselmoleküle ITG
Erschienen in BMC Biology
Verlag Springer Fachmedien Wiesbaden
Band 12
Seiten 13
Schlagwörter Organizer activity; Signaling; Forebrain; Habenula; Thalamus; Mice; Zebrafish
Nachgewiesen in Dimensions
Scopus
Web of Science
KIT – Die Forschungsuniversität in der Helmholtz-Gemeinschaft
KITopen Landing Page