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Liquid polystyrene: a room-temperature photocurable soft lithography compatible pour-and-cure-type polystyrene

Nargang, Tobias M.; Brockmann, Lara; Nikolov, Pavel Mitkov; Schild, Dieter; Helmer, Dorothea; Keller, Nico; Sachsenheimer, Kai; Wilhelm, Elisabeth; Pires, Leonardo; Dirschka, Marian; Kolew, Alexander; Schneider, Marc; Worgull, Matthias; Giselbrecht, Stefan; Neumann, Christiane; Rapp, Bastian E.

Materials matter in microfluidics. Since the introduction of soft lithography as a prototyping technique and polydimethylsiloxane (PDMS) as material of choice the microfluidics community has settled with using this material almost exclusively. However{,} for many applications PDMS is not an ideal material given its limited solvent resistance and hydrophobicity which makes it especially disadvantageous for certain cell-based assays. For these applications polystyrene (PS) would be a better choice. PS has been used in biology research and analytics for decades and numerous protocols have been developed and optimized for it. However{,} PS has not found widespread use in microfluidics mainly because{,} being a thermoplastic material{,} it is typically structured using industrial polymer replication techniques. This makes PS unsuitable for prototyping. In this paper{,} we introduce a new structuring method for PS which is compatible with soft lithography prototyping. We develop a liquid PS prepolymer which we term as {"}Liquid Polystyrene{"} (liqPS). liqPS is a viscous free-flowing liquid which can be cured by visible light exposure using soft replication templates{,} e.g.{,} made from PDMS. ... mehr

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DOI: 10.5445/IR/1000046548
DOI: 10.1039/C4LC00045E
Zitationen: 17
Web of Science
Zitationen: 16
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Baugestaltung (Inst. f. Baugest.)
Institut für Mikrostrukturtechnik (IMT)
Institut für Nukleare Entsorgung (INE)
Institut für Biologische Grenzflächen (IBG)
Karlsruhe Nano Micro Facility (KNMF)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2014
Sprache Englisch
Identifikator ISSN: 1473-0189, 1473-0197
KITopen-ID: 1000046548
HGF-Programm 47.01.03 (POF II, LK 01)
Biologische Schlüselmoleküle IMT
Erschienen in Lab on a chip
Band 14
Heft 15
Seiten 2698-2708
Bemerkung zur Veröffentlichung RSC geförderter Open Access-Artikel
Nachgewiesen in Web of Science
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