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CD44 acts as a signaling platform controlling tumor progression and metastasis

Orian-Rousseau, Veronique

Abstract:
Members of the CD44 family of transmembrane glycoproteins emerge as major signal transduction control units. CD44 isoforms participate in several signaling pathways ranging from growth factor-induced signaling to Wnt-regulated pathways. The role of the CD44 family members in tumor progression and metastasis is most likely linked to the function of the various isoforms as signaling hubs. Increasing evidence suggests that these proteins are not solely cancer stem cell (CSC) markers but are directly involved in tumor and metastasis initiation. It is foreseeable that a link between the expression of CD44 isoforms in CSCs and their function as signaling regulators will be drawn in a near future.

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Volltext §
DOI: 10.5445/IR/1000046956
Originalveröffentlichung
DOI: 10.3389/fimmu.2015.00154
Scopus
Zitationen: 65
Web of Science
Zitationen: 63
Coverbild
Zugehörige Institution(en) am KIT Institut für Toxikologie und Genetik (ITG)
Publikationstyp Zeitschriftenaufsatz
Jahr 2015
Sprache Englisch
Identifikator ISSN: 1664-3224
urn:nbn:de:swb:90-469566
KITopen-ID: 1000046956
HGF-Programm 47.01.01 (POF III, LK 01)
Erschienen in Frontiers in immunology
Band 6
Heft 154
Seiten 1-4
Bemerkung zur Veröffentlichung Gefördert durch den KIT-Publikationsfonds
Schlagworte CD44, RTK, cancer stem cells, alternative splicing, EMT
Nachgewiesen in Scopus
Web of Science
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