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In Situ Magnetic Separation on Pilot Scale: A Tool for Process Optimization

Scholz, Alexander; Cerff, Martin; Posten, Clemens

Abstract:

This study describes the design and development of an in situ magnetic separation process (ISMS) based on the use of ion exchange functionalized magnetic particles. ISMS as a tool for in situ product removal (ISPR) has the potential to increase the performance of a biotechnological production process comprehensively by improving the bioprocess itself and the downstream processing simultaneously. The successful implementation of this concept requires the systematic examination and optimization of the different ISMS subsystem. Hence, this report presents detailed characterization data for the magnetic particle system, the magnetic separator, and the bioprocess. For each system, specific requirements were defined and subsequently applied to identify suitable process components. In this context always economic considerations were also accounted to enable the application of this new process as cost-efficiently as possible. Especially the selection and modification of a magnetic particle system and the development of a low-cost magnetic separator were subjected to these basic criteria. For the final verification of the ISMS effects, all components were brought together in a pilot scale system and used to perform cultivation with integrated ISPR. ... mehr


Originalveröffentlichung
DOI: 10.1007/978-3-662-43899-2_11
Zugehörige Institution(en) am KIT Institut für Bio- und Lebensmitteltechnik (BLT)
Publikationstyp Buchaufsatz
Publikationsjahr 2014
Sprache Englisch
Identifikator ISBN: 978-3-662-43898-5
KITopen-ID: 1000047435
HGF-Programm 35.02 (POF II, LK 01) Biomasse für chemische Energieträger
Erschienen in Upscaling of bio-nano-processes : selective bioseparation by magnetic particles. Ed.: H. Nirschl
Verlag Springer Verlag
Seiten 189-211
Serie Lecture notes in bioengineering
Nachgewiesen in Dimensions
KIT – Die Forschungsuniversität in der Helmholtz-Gemeinschaft
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