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Characterisation and application of ultra-high spin clusters as magnetic resonance relaxation agents

Guthausen, Gisela; Machado, Julyana R.; Luy, Burkhard; Baniodeh, Amer; Powell, Annie K.; Kramer, Steffen; Ranzinger, Florian; Herrling, Maria P.; Lackner, Susanne; Horn, Harald

Abstract:
In Magnetic Resonance Tomography (MRT) image contrast can be improved by adding paramagnetic relaxation agents such as lanthanide ions. Here we report on the use of highly paramagnetic isostructural FeIII/4f coordination clusters with a [Fe10Ln10] core to enhance relaxation. Measurements were performed over the range of 1H Larmor frequencies of 10 MHz to 1.4 GHz in order to determine the relevant parameters for longitudinal and transverse relaxivities. Variation of the lanthanide ion allows differentiation of relaxation contributions from electronic states and molecular dynamics. We find that the transverse relaxivities increase with field, whereas the longitudinal relaxivities depend on the nature of the lanthanide. In addition, the GdIII analogue was selected in particular to test the interaction with tissue observed using MRT. Studies on biofilms used in waste water treatment reveal that the behaviour of the high-spin clusters is different from what is observed for common relaxation agents with respect to the penetration into the biofilms. The Fe10Gd10 cluster adheres to the surface of the biofilm better than the commercial agent Gadovist.

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Volltext §
DOI: 10.5445/IR/1000047599
Originalveröffentlichung
DOI: 10.1039/C4DT02916J
Scopus
Zitationen: 15
Web of Science
Zitationen: 15
Coverbild
Zugehörige Institution(en) am KIT Engler-Bunte-Institut (EBI)
Institut für Mechanische Verfahrenstechnik und Mechanik (MVM)
Institut für Nanotechnologie (INT)
Institut für Biologische Grenzflächen (IBG)
Publikationstyp Zeitschriftenaufsatz
Jahr 2015
Sprache Englisch
Identifikator ISSN: 1477-9226
urn:nbn:de:swb:90-475993
KITopen-ID: 1000047599
HGF-Programm 47.02.04 (POF III, LK 01)
Erschienen in Dalton Transactions
Band 44
Heft 11
Seiten 5032-5040
Bemerkung zur Veröffentlichung RSC geförderter Open Access-Artikel
Nachgewiesen in Web of Science
Scopus
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