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Surface Acoustic Wave (SAW) Resonators for Monitoring Conditioning Film Formation

Hohmann, Siegfried; Kögel, Svea; Brunner, Yvonne; Schmieg, Barbara; Ewald, Christina; Kirschhöfer, Frank; Brenner-Weiß, Gerald; Länge, Kerstin

We propose surface acoustic wave (SAW) resonators as a complementary tool for conditioning film monitoring. Conditioning films are formed by adsorption of inorganic and organic substances on a substrate the moment this substrate comes into contact with a liquid phase. In the case of implant insertion, for instance, initial protein adsorption is required to start wound healing, but it will also trigger immune reactions leading to inflammatory responses. The control of the initial protein adsorption would allow to promote the healing process and to suppress adverse immune reactions. Methods to investigate these adsorption processes are available, but it remains difficult to translate measurement results into actual protein binding events. Biosensor transducers allow user-friendly investigation of protein adsorption on different surfaces. The combination of several transduction principles leads to complementary results, allowing a more comprehensive characterization of the adsorbing layer. We introduce SAW resonators as a novel complementary tool for time-resolved conditioning film monitoring. SAW resonators were coated with polymers. The adsorption of the plasma proteins human serum albumin (HSA) and fibrinogen onto the polymer-coated surfaces were monitored. ... mehr

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Volltext §
DOI: 10.5445/IR/1000048012
DOI: 10.3390/s150511873
Zitationen: 12
Web of Science
Zitationen: 12
Zugehörige Institution(en) am KIT Institut für Mikrostrukturtechnik (IMT)
Institut für Funktionelle Grenzflächen (IFG)
Publikationstyp Zeitschriftenaufsatz
Jahr 2015
Sprache Englisch
Identifikator ISSN: 1424-8220
KITopen-ID: 1000048012
HGF-Programm 47.02.07 (POF III, LK 01)
Erschienen in Sensors
Band 15
Heft 5
Seiten 11873-11888
Bemerkung zur Veröffentlichung Gefördert durch den KIT-Publikationsfonds
Schlagworte surface acoustic wave (SAW); two-port resonator; conditioning film; human serum albumin (HSA); fibrinogen; plasma protein; implants; quartz crystal microbalance (QCM-D); polymer
Nachgewiesen in Web of Science
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