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URN: urn:nbn:de:swb:90-480403

Improving Motor Activity Assessment in Depression: Which Sensor Placement, Analytic Strategy and Diurnal Time Frame Are Most Powerful in Distinguishing Patients from Controls and Monitoring Treatment Effects

Reichert, Markus; Lutz, Alexander; Deuschle, Michael; Gilles, Maria; Hill, Holger; Limberger, Matthias F.; Ebner-Priemer, Ulrich W.

Abstract:
Background
Abnormalities in motor activity represent a central feature in major depressive disorder. However, measurement issues are poorly understood, limiting the use of objective measurement of motor activity for diagnostics and treatment monitoring.
Methods
To improve measurement issues, especially sensor placement, analytic strategies and diurnal effects, we assessed motor activity in depressed patients at the beginning (MD; n=27) and after anti-depressive treatment (MD-post; n=18) as well as in healthy controls (HC; n=16) using wrist- and chest-worn accelerometers. We performed multiple analyses regarding sensor placements, extracted features, diurnal variation, motion patterns and posture to clarify which parameters are most powerful in distinguishing patients from controls and monitoring treatment effects.
Results
Whereas most feature-placement combinations revealed significant differences between groups, acceleration (wrist) distinguished MD from HC (d=1.39) best. Frequency (vertical axis chest) additionally differentiated groups in a logistic regression model (R2=0.54). Accordingly, both amplitude (d=1.16) and frequen ... mehr


Zugehörige Institution(en) am KIT Institut für Sport und Sportwissenschaft (IfSS)
Publikationstyp Zeitschriftenaufsatz
Jahr 2015
Sprache Englisch
Identifikator ISSN: 1932-6203
KITopen ID: 1000048040
Erschienen in PLoS ONE
Band 10
Heft 4
Seiten e0124231
Bemerkung zur Veröffentlichung Gefördert durch den KIT-Publikationsfonds
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