KIT | KIT-Bibliothek | Impressum | Datenschutz

Improving Motor Activity Assessment in Depression: Which Sensor Placement, Analytic Strategy and Diurnal Time Frame Are Most Powerful in Distinguishing Patients from Controls and Monitoring Treatment Effects

Reichert, Markus 1; Lutz, Alexander; Deuschle, Michael; Gilles, Maria; Hill, Holger 1; Limberger, Matthias F. 1; Ebner-Priemer, Ulrich W. 1
1 Karlsruher Institut für Technologie (KIT)


Abnormalities in motor activity represent a central feature in major depressive disorder. However, measurement issues are poorly understood, limiting the use of objective measurement of motor activity for diagnostics and treatment monitoring.
To improve measurement issues, especially sensor placement, analytic strategies and diurnal effects, we assessed motor activity in depressed patients at the beginning (MD; n=27) and after anti-depressive treatment (MD-post; n=18) as well as in healthy controls (HC; n=16) using wrist- and chest-worn accelerometers. We performed multiple analyses regarding sensor placements, extracted features, diurnal variation, motion patterns and posture to clarify which parameters are most powerful in distinguishing patients from controls and monitoring treatment effects.
Whereas most feature-placement combinations revealed significant differences between groups, acceleration (wrist) distinguished MD from HC (d=1.39) best. Frequency (vertical axis chest) additionally differentiated groups in a logistic regression model (R2=0.54). Accordingly, both amplitude (d=1.16) and frequency (d=1.04) showed alterations, indicating reduced and decelerated motor activity. ... mehr

Verlagsausgabe §
DOI: 10.5445/IR/1000048040
Veröffentlicht am 26.09.2018
DOI: 10.1371/journal.pone.0124231
Zitationen: 20
Web of Science
Zitationen: 16
Zitationen: 23
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Sport und Sportwissenschaft (IfSS)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2015
Sprache Englisch
Identifikator ISSN: 1932-6203
KITopen-ID: 1000048040
Erschienen in PLoS one
Verlag Public Library of Science (PLoS)
Band 10
Heft 4
Seiten e0124231
Bemerkung zur Veröffentlichung Gefördert durch den KIT-Publikationsfonds
Nachgewiesen in Dimensions
Web of Science
KIT – Die Forschungsuniversität in der Helmholtz-Gemeinschaft
KITopen Landing Page