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Lipase-catalyzed synthesis of glucose-6-O-hexanoate in deep eutectic solvents

Pöhnlein, Martin; Ulrich, Jonas Ulrich; Kirschhöfer, Frank; Nusser, Michael; Muhle-Goll, Claudia; Kannengiesser, Bastian; Brenner-Weiß, Gerald; Luy, Burkhard; Liese, Andreas; Syldatk, Christoph; Hausmann, Rudolf

Abstract:
Enzymatic synthesis of sugar fatty acid esters in organic solvents is a well-described procedure to synthesize glycolipids. This study aims at replacing these solvents with deep eutectic solvents (DES), a group of solvents that gained more and more interest during the last years, since they can be easily produced from non-toxic resources. Enzymatic glycolipid synthesis in deep eutectic solvents was investigated, employing Candida antarctica lipase B (Novozyme 435) in various deep eutectic solvents. A successful lipase-catalyzed synthesis of glucose fatty acid esters gave proof of this concept, while using the two deep eutectic solvents consisting of choline chloride and urea (CC : U) and choline chloride and glucose (CC : Glc). Additionally the DES consisting of choline chloride and glucose was observed to act as solvent and substrate for the synthesis at the same time.
1 Practical applications

Glycolipids find applications in many everyday products like cosmetic and pharmaceutical formulations, food and classic cleaning products, utilizing their good detergent or emulsification properties. Glycolipids can, among other routes, b ... mehr


Zugehörige Institution(en) am KIT Institut für Biologische Grenzflächen (IBG)
Institut für Bio- und Lebensmitteltechnik (BLT)
Publikationstyp Zeitschriftenaufsatz
Jahr 2015
Sprache Englisch
Identifikator DOI: 10.1002/ejlt.201400459
ISSN: 1438-7697
KITopen ID: 1000048166
HGF-Programm 47.02.04; LK 01
Erschienen in European Journal of Lipid Science and Technology
Band 117
Heft 2
Seiten 161-166
Bemerkung zur Veröffentlichung Article first published online: 30 JAN 2015
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