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Lipase-catalyzed synthesis of glucose-6-O-hexanoate in deep eutectic solvents

Pöhnlein, Martin 1; Ulrich, Jonas 1; Kirschhöfer, Frank 2; Nusser, Michael 2; Muhle-Goll, Claudia ORCID iD icon 3; Kannengiesser, Bastian; Brenner-Weiß, Gerald 2; Luy, Burkhard ORCID iD icon 3,4; Liese, Andreas; Syldatk, Christoph 1; Hausmann, Rudolf
1 Institut für Bio- und Lebensmitteltechnik (BLT), Karlsruher Institut für Technologie (KIT)
2 Institut für Funktionelle Grenzflächen (IFG), Karlsruher Institut für Technologie (KIT)
3 Institut für Organische Chemie (IOC), Karlsruher Institut für Technologie (KIT)
4 Institut für Biologische Grenzflächen (IBG), Karlsruher Institut für Technologie (KIT)


Enzymatic synthesis of sugar fatty acid esters in organic solvents is a well-described procedure to synthesize glycolipids. This study aims at replacing these solvents with deep eutectic solvents (DES), a group of solvents that gained more and more interest during the last years, since they can be easily produced from non-toxic resources. Enzymatic glycolipid synthesis in deep eutectic solvents was investigated, employing Candida antarctica lipase B (Novozyme 435) in various deep eutectic solvents. A successful lipase-catalyzed synthesis of glucose fatty acid esters gave proof of this concept, while using the two deep eutectic solvents consisting of choline chloride and urea (CC : U) and choline chloride and glucose (CC : Glc). Additionally the DES consisting of choline chloride and glucose was observed to act as solvent and substrate for the synthesis at the same time.
1 Practical applications

Glycolipids find applications in many everyday products like cosmetic and pharmaceutical formulations, food and classic cleaning products, utilizing their good detergent or emulsification properties. Glycolipids can, among other routes, be synthesized via lipase-catalyzed reactions, which are often carried out in organic solvents. ... mehr

DOI: 10.1002/ejlt.201400459
Zitationen: 59
Zitationen: 62
Zugehörige Institution(en) am KIT Institut für Biologische Grenzflächen (IBG)
Institut für Bio- und Lebensmitteltechnik (BLT)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2015
Sprache Englisch
Identifikator ISSN: 0015-038X, 0367-2107, 0367-3278, 0931-5985, 1438-7697, 1438-9312, 1521-4133
KITopen-ID: 1000048166
HGF-Programm 47.02.04 (POF III, LK 01) Zellpopul.auf Biofunk.Oberflächen IBG-4
Erschienen in European journal of lipid science and technology
Verlag John Wiley and Sons
Band 117
Heft 2
Seiten 161-166
Vorab online veröffentlicht am 30.01.2015
Nachgewiesen in Scopus
Web of Science
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