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Characterization of Phase Behavior and Protein Interactions of Monoclonal Antibodies

Rakel, Natalie

Abstract:
Monoclonal antibodies are one of the fastest growing product classes in biopharmaceutics. Screening strategies for phase behavior and interactions of these proteins are established in this work. Experimental results are compared with empirical and thermodynamic approaches. Gained knowledge will reduce efforts in crystallization condition screening and optimization of other downstream processing steps.

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Volltext §
DOI: 10.5445/IR/1000049129
Zugehörige Institution(en) am KIT Institut für Bio- und Lebensmitteltechnik (BLT)
Publikationstyp Hochschulschrift
Jahr 2015
Sprache Englisch
Identifikator urn:nbn:de:swb:90-491297
KITopen-ID: 1000049129
Verlag KIT, Karlsruhe
Abschlussart Dissertation
Fakultät Fakultät für Chemieingenieurwesen und Verfahrenstechnik (CIW)
Institut Institut für Bio- und Lebensmitteltechnik (BLT)
Prüfungsdaten 24.04.2015
Referent/Betreuer Prof. J. Hubbuch
Schlagworte Protein phase behavior, Crystallization, Protein interactions, Monoclonal antibodies, High throughput screening
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