Characterization of Phase Behavior and Protein Interactions of Monoclonal Antibodies
Abstract:
Monoclonal antibodies are one of the fastest growing product classes in biopharmaceutics. Screening strategies for phase behavior and interactions of these proteins are established in this work. Experimental results are compared with empirical and thermodynamic approaches. Gained knowledge will reduce efforts in crystallization condition screening and optimization of other downstream processing steps.
| Zugehörige Institution(en) am KIT | Institut für Bio- und Lebensmitteltechnik (BLT) |
| Publikationstyp | Hochschulschrift |
| Publikationsjahr | 2015 |
| Sprache | Englisch |
| Identifikator | urn:nbn:de:swb:90-491297 KITopen-ID: 1000049129 |
| Verlag | Karlsruher Institut für Technologie (KIT) |
| Art der Arbeit | Dissertation |
| Fakultät | Fakultät für Chemieingenieurwesen und Verfahrenstechnik (CIW) |
| Institut | Institut für Bio- und Lebensmitteltechnik (BLT) |
| Prüfungsdaten | 24.04.2015 |
| Schlagwörter | Protein phase behavior, Crystallization, Protein interactions, Monoclonal antibodies, High throughput screening |
| Referent/Betreuer | Hubbuch, J. |