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Originalveröffentlichung
DOI: 10.1371/journal.pone.0090884
Scopus
Zitationen: 6
Web of Science
Zitationen: 6

Nano-scale morphology of melanosomes revealed by small-angle X-ray scattering

Gorniak, T.; Haraszti, T.; Garamus, V.M.; Buck, A.R.; Senkbeil, T.; Priebe, M.; Hedberg-Buenz, A.; Koehn, D.; Salditt, T.; Grunze, M.; Anderson, M.G.; Rosenhahn, A.

Abstract:
Melanosomes are highly specialized organelles that produce and store the pigment melanin, thereby fulfilling essential functions within their host organism. Besides having obvious cosmetic consequences – determining the color of skin, hair and the iris – they contribute to photochemical protection from ultraviolet radiation, as well as to vision (by defining how much light enters the eye). Though melanosomes can be beneficial for health, abnormalities in their structure can lead to adverse effects. Knowledge of their ultrastructure will be crucial to gaining insight into the mechanisms that ultimately lead to melanosome-related diseases. However, due to their small size and electron-dense content, physiologically intact melanosomes are recalcitrant to study by common imaging techniques such as light and transmission electron microscopy. In contrast, X-ray-based methodologies offer both high spatial resolution and powerful penetrating capabilities, and thus are well suited to study the ultrastructure of electron-dense organelles in their natural, hydrated form. Here, we report on the application of small-angle X-ray scattering – a me ... mehr


Zugehörige Institution(en) am KIT Institut für Funktionelle Grenzflächen (IFG)
Publikationstyp Zeitschriftenaufsatz
Jahr 2014
Sprache Englisch
Identifikator ISSN: 1932-6203
URN: urn:nbn:de:swb:90-492341
KITopen ID: 1000049234
HGF-Programm 47.04.02; LK 01
Erschienen in PLoS one
Band 9
Heft 3
Seiten e90884
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