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DOI: 10.5445/IR/1000050054

Host Matrix Modulation by Tumor Exosomal CD44v6 and Proteases Promotes Motility and Invasiveness

Mu, Wei

Abstract:
Tumor exosomes (TEX) severely influence hematopoiesis and premetastatic organ cells. With the extracellular matrix (ECM) being an essential constituent of non-transformed tissues and tumors, we asked whether exosomes from a metastatic rat tumor also affect the organization of the ECM. Matrix degradation by TEX has severe consequences on host cell adhesion, motility, and invasiveness. Taken together, ECM modulation is an important factor in the cross talk between a tumor and the host cells.


Zugehörige Institution(en) am KIT Institut für Toxikologie und Genetik (ITG)
Publikationstyp Hochschulschrift
Jahr 2015
Sprache Englisch
Identifikator URN: urn:nbn:de:swb:90-500546
KITopen ID: 1000050054
Verlag Karlsruhe
Abschlussart Dissertation
Fakultät Fakultät für Chemie und Biowissenschaften (CHEM-BIO)
Institut Institut für Toxikologie und Genetik (ITG)
Prüfungsdaten 23.10.2015
Referent/Betreuer Prof. A. Cato
Schlagworte tumor exosomes, extracellular matrix, proteases, CD44v6
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