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Simultaneous ¹⁹F-¹H medium resolution NMR spectroscopy for online reaction monitoring

Zientek, Nicolai; Laurain, Clement; Meyer, Klas; Kraume, Matthias; Guthausen, Gisela; Maiwald, Michael

Abstract:
Medium resolution nuclear magnetic resonance (MR-NMR) spectroscopy is currently a fast developing field, which has an enormous potential to become an important analytical tool for reaction monitoring, in hyphenated techniques, and for systematic investigations of complex mixtures. The recent developments of innovative MR-NMR spectrometers are therefore remarkable due to their possible applications in quality control, education, and process monitoring. MR-NMR spectroscopy can beneficially be applied for fast, non-invasive, and volume integrating analyses under rough environmental conditions.
Within this study, a simple 1/16 '' fluorinated ethylene propylene (FEP) tube with an ID of 0.04 '' (1.02 mm) was used as a flow cell in combination with a 5 mm glass Dewar tube inserted into a benchtop MR-NMR spectrometer with a H-1 Larmor frequency of 43.32 MHz and 40.68 MHz for F-19. For the first time, quasi-simultaneous proton and fluorine NMR spectra were recorded with a series of alternating F-19 and H-1 single scan spectra along the reaction time coordiriate of a homogeneously catalysed esterification model reaction containing fluorinate ... mehr


Zugehörige Institution(en) am KIT Institut für Biologische Grenzflächen (IBG)
Institut für Mechanische Verfahrenstechnik und Mechanik (MVM)
Publikationstyp Zeitschriftenaufsatz
Jahr 2014
Sprache Englisch
Identifikator DOI: 10.1016/j.jmr.2014.10.007
ISSN: 1090-7807
KITopen ID: 1000050584
HGF-Programm 47.02.02; LK 01
Erschienen in Journal of Magnetic Resonance
Band 249
Seiten 53-62
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