Photoswitchable peptidomimetics with diarylethene building blocks

Incorporation of molecular photoswitches into peptides or proteins should allow reversible control of their structure and functions by means of photoisomerization. The aim of this study was to explore the practical possibilities of polypeptide modification using photoswitchable diarylethene-based building blocks, and to investigate the effects of the photoinduced isomerization on the structure and function of several biologically active peptides.