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Novel development tools for processing of recombinant virus-like particles

Ladd Effio, Christopher

Abstract:
The focus of this thesis is laid on the implementation of integrated bioprocesses and the development of novel methods for recombinant protein-based virus-like particles (VLPs). Due to their pathogen-associated molecular patterns and the lack of viral nucleic acids, VLPs represent promising bionanoparticles for vaccine applications. This thesis aims to generate straightforward production, purification and analytical procedures for VLPs by advancing rational design tools for large biomolecules.


Zugehörige Institution(en) am KIT Institut für Bio- und Lebensmitteltechnik (BLT)
Publikationstyp Hochschulschrift
Jahr 2016
Sprache Englisch
Identifikator DOI(KIT): 10.5445/IR/1000052361
URN: urn:nbn:de:swb:90-523619
KITopen ID: 1000052361
Verlag Karlsruhe
Abschlussart Dissertation
Fakultät Fakultät für Chemieingenieurwesen und Verfahrenstechnik (CIW)
Institut Institut für Bio- und Lebensmitteltechnik (BLT)
Prüfungsdaten 05.02.2016
Referent/Betreuer Prof. J. Hubbuch
Schlagworte Virus-like particle vaccines, High-throughput screening, Downstream Processing, Membrane Chromatography, Aqueous Two-Phase Extraction
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