KIT | KIT-Bibliothek | Impressum | Datenschutz

Biodegradable Peptide-Silica Nanodonuts

Maggini, Laura; Travaglini, Leana; Cabrera, Ingrid; Castro-Hartmann, Pablo; De Cola, Luisa 1
1 Karlsruher Institut für Technologie (KIT)

Abstract (englisch):

We report hybrid organosilica toroidal particles containing a short peptide sequence as the organic component of the hybrid systems. Once internalised in cancer cells, the presence of the peptide allows for interaction with peptidase enzymes, which attack the nanocarrier effectively triggering its structural breakdown. Moreover, these biodegradable nanovectors are characterised by high cellular uptake and exocytosis, showing great potential as biodegradable drug carriers. To demonstrate this feature, doxorubicin was employed and its delivery in HeLa cells investigated.

DOI: 10.1002/chem.201504605
Zitationen: 33
Web of Science
Zitationen: 32
Zitationen: 35
Zugehörige Institution(en) am KIT Institut für Nanotechnologie (INT)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2016
Sprache Englisch
Identifikator ISSN: 0947-6539
KITopen-ID: 1000053877
HGF-Programm 43.21.04 (POF III, LK 01) Molecular Engineering
Erschienen in Chemistry - A European Journal
Verlag John Wiley and Sons
Band 22
Heft 11
Seiten 3697-3703
Nachgewiesen in Web of Science
KIT – Die Forschungsuniversität in der Helmholtz-Gemeinschaft
KITopen Landing Page