A consistent interpretation of the Higgs data requires the same precision in the Higgs boson masses and in the trilinear Higgs self-couplings, which are related through their common origin from the Higgs potential. In this work we provide the two-loop corrections at O α t α s O(αtαs) in the approximation of vanishing external momenta to the trilinear Higgs self-couplings in the CP-violating Next-to-Minimal Supersymmetric extension of the Standard Model (NMSSM). In the top/stop sector two different renormalization schemes have been implemented, the OS and the D R ¯ DR¯¯¯¯¯ scheme. The two-loop corrections to the self-couplings are of the order of 10% in the investigated scenarios. The theoretical error, estimated both from the variation of the renormalization scale and from the change of the top/stop sector renormalization scheme, has been shown to be reduced due to the inclusion of the two-loop corrections.