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Whole transcriptome data analysis of zebrafish mutants affecting muscle development

Armant, Olivier; Gourain, Victor; Etard, Christelle; Strähle, Uwe

Abstract:
Formation of the contractile myofibril of the skeletal muscle is a complex process which when perturbed leads to muscular dystrophy. Herein, we provide a mRNAseq dataset on three different zebrafish mutants affecting muscle organization during embryogenesis. These comprise the myosin folding chaperone unc45b (unc45b_/_), heat shock protein 90aa1.1 (hsp90aa1.1_/_) and the acetylcholine esterase (ache_/_) gene. The transcriptome analysis was performed in duplicate experiments at 72h post-fertilization (hpf) for all three mutants, with two additional times of development( 24hpf and 48 hpf) for unc45b_/_. A total of 20 samples were analyzed by hierarchical clustering for differential gene expression. The data from this study support the observation made in Etard et al. (2015) [1] (http://dx.doi.org/10.1186/s13059-015-0825-8) that a failure to fold myosin activates a unique transcriptional program in the skeletal muscles that isdifferent from that induced in stressed muscle cells

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Volltext §
DOI: 10.5445/IR/1000055088
Originalveröffentlichung
DOI: 10.1016/j.dib.2016.05.007
Scopus
Zitationen: 2
Coverbild
Zugehörige Institution(en) am KIT Institut für Toxikologie und Genetik (ITG)
Publikationstyp Zeitschriftenaufsatz
Jahr 2016
Sprache Englisch
Identifikator ISSN: 2352-3409
urn:nbn:de:swb:90-550886
KITopen-ID: 1000055088
HGF-Programm 47.01.01 (POF III, LK 01)
Erschienen in Data in Brief
Band 8
Seiten 61-68
Bemerkung zur Veröffentlichung Gefördert durch den KIT-Publikationsfonds
Schlagworte Genetics, mRNASeq, Zebrafish, Muscle mutant, Development
Nachgewiesen in Scopus
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