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Age-related Changes of Plasma Bile Acid Concentrations in Healthy Adults : Results from the Cross-Sectional KarMeN Study

Frommherz, Lara; Bub, Achim; Hummel, Eva; Rist, Manuela J.; Roth, Alexander; Watzl, Bernhard; Kulling, Sabine E.

Bile acids (BA) play an important role in lipid metabolism. They facilitate intestinal lipid absorption, and BA synthesis is the main catabolic pathway for cholesterol. The objective of this study was to investigate associations of age, sex, diet (fat intake) and parameters of lipid metabolism (triglycerides, LDL, HDL, body fat content) with fasting plasma BA concentration of healthy individuals. Fasting plasma samples from a cross-sectional study were used to determine the concentrations of 14 BA using an LC-MS stable isotope dilution assay. Triglycerides, LDL and HDL were analyzed by standard clinical chemistry methods and body fat content was measured with a DXA instrument. The dietary fat intake of the 24 h period prior to the sampling was assessed on the basis of a 24 h recall. Subsequent statistical data processing was done by means of a median regression model. Results revealed large inter-individual variations. Overall, higher median plasma concentrations of BA were observed in men than in women. Quantile regression showed significant interactions of selected BA with age and sex, affecting primarily chenodeoxycholic acid and its conjugates. ... mehr

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Verlagsausgabe §
DOI: 10.5445/IR/1000056243
Veröffentlicht am 17.01.2018
DOI: 10.1371/journal.pone.0153959
Zitationen: 23
Web of Science
Zitationen: 24
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Sport und Sportwissenschaft (IfSS)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2016
Sprache Englisch
Identifikator ISSN: 1932-6203
KITopen-ID: 1000056243
Erschienen in PLoS one
Verlag Public Library of Science (PLoS)
Band 11
Heft 4
Seiten Art.Nr. e0153959
Nachgewiesen in Web of Science
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