Computational and Experimental Characterization of Proteins With Respect to Protein-Solvent Interactions

The complexity of biopharmaceuticals requires intensive protein characterization and a thorough study of production processes to ensure process efficiency, product quality, and most notably patient safety. The present work focuses on the investigation of the interactions between proteins and aqueous solvents. Therefore appropriate methods for assessing protein characteristics were developed and protein phase behavior and protein partitioning in aqueous two phase systems were investigated.