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Characterization of complex fractionated atrial electrograms by sample entropy: An international multi-center study

Cirugeda-Roldán, E.; Novak, D.; Kremen, V.; Cuesta-Frau, D.; Keller, M.; Luik, A.; Srutova, M.

Atrial fibrillation (AF) is the most commonly clinically-encountered arrhythmia. Catheter ablation of AF is mainly based on trigger elimination and modification of the AF substrate. Substrate mapping ablation of complex fractionated atrial electrograms (CFAEs) has emerged to be a promising technique. To improve substrate mapping based on CFAE analysis, automatic detection algorithms need to be developed in order to simplify and accelerate the ablation procedures. According to the latest studies, the level of fractionation has been shown to be promisingly well estimated from CFAE measured during radio frequency (RF) ablation of AF. The nature of CFAE is generally nonlinear and nonstationary, so the use of complexity measures is considered to be the appropriate technique for the analysis of AF records. This work proposes the use of sample entropy (SampEn), not only as a way to discern between non-fractionated and fractionated atrial electrograms (A-EGM), but also as a tool for characterizing the degree of A-EGM regularity, which is linked to changes in the AF substrate and to heart tissue damage. The use of SampEn combined with a blin ... mehr

Zugehörige Institution(en) am KIT Institut für Biomedizinische Technik (IBT)
Publikationstyp Zeitschriftenaufsatz
Jahr 2015
Sprache Englisch
Identifikator DOI: 10.3390/e17117493
ISSN: 1099-4300
URN: urn:nbn:de:swb:90-569334
KITopen ID: 1000056933
Erschienen in Entropy
Band 17
Heft 11
Seiten 7493-7509
Lizenz CC BY 4.0: Creative Commons Namensnennung 4.0 International
Schlagworte atrial fibrillation, catheter ablation, complex fractionated atrial electrograms, sample entropy, signal classification
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