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Impact of adjustable cryogel properties on the performance of prostate cancer cells in 3D

Bäcker, A. 1; Göppert, B. 1; Sturm, S. 1; Abaffy, P. 1; Sollich, T. 2; Gruhl, F. J. 1
1 Institut für Mikrostrukturtechnik (IMT), Karlsruher Institut für Technologie (KIT)
2 Institut für Funktionelle Grenzflächen (IFG), Karlsruher Institut für Technologie (KIT)

Abstract:

Background: Biochemical and physical characteristics of extracellular environment
play a key role in assisting cell behavior over different molecular pathways. In this study,
we investigated how the presence of chemical binding sites, the pore network and the
stiffness of designed scaffolds affected prostate cancer cells.
Methods: A blend of poly hydroxyethyl methacrylate–alginate–gelatin scaffold was
synthesized by cryogelation process using polyethyleneglycol diacrylate (PEGda) and
glutaraldehyde as cross linkers. The chemical and mechanical scaffold properties were
... mehr

Abstract (englisch):

Background

Biochemical and physical characteristics of extracellular environment play a key role in assisting cell behavior over different molecular pathways. In this study, we investigated how the presence of chemical binding sites, the pore network and the stiffness of designed scaffolds affected prostate cancer cells.
Methods

A blend of poly hydroxyethyl methacrylate–alginate–gelatin scaffold was synthesized by cryogelation process using polyethyleneglycol diacrylate (PEGda) and glutaraldehyde as cross linkers. The chemical and mechanical scaffold properties were varied by concentration of gelatin and PEGda, respectively. ... mehr


Volltext §
DOI: 10.5445/IR/1000057716
Originalveröffentlichung
DOI: 10.1186/s40064-016-2629-z
Scopus
Zitationen: 16
Web of Science
Zitationen: 15
Dimensions
Zitationen: 16
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Funktionelle Grenzflächen (IFG)
Institut für Mikrostrukturtechnik (IMT)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2016
Sprache Englisch
Identifikator ISSN: 2193-1801
urn:nbn:de:swb:90-577168
KITopen-ID: 1000057716
HGF-Programm 47.02.07 (POF III, LK 01) Zellpopul.auf Biofunk.Oberflächen IMT
Erschienen in SpringerPlus
Verlag Springer Fachmedien Wiesbaden
Band 5
Heft 1
Seiten 902
Bemerkung zur Veröffentlichung Gefördert durch den KIT-Publikationsfonds
Vorab online veröffentlicht am 27.06.2016
Schlagwörter Cryogel, Stiffness, Porosity, 3D cell culture, Prostate cancer, Androgen receptor (AR) localization
Nachgewiesen in Dimensions
Web of Science
Scopus
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