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Impact of adjustable cryogel properties on the performance of prostate cancer cells in 3D

Bäcker, A.; Göppert, B.; Sturm, S.; Abaffy, P.; Sollich, T.; Gruhl, F.J.

Abstract:
Background: Biochemical and physical characteristics of extracellular environment
play a key role in assisting cell behavior over different molecular pathways. In this study,
we investigated how the presence of chemical binding sites, the pore network and the
stiffness of designed scaffolds affected prostate cancer cells.
Methods: A blend of poly hydroxyethyl methacrylate–alginate–gelatin scaffold was
synthesized by cryogelation process using polyethyleneglycol diacrylate (PEGda) and
glutaraldehyde as cross linkers. The chemical and mechanical scaffold properties ... mehr

Abstract (englisch):
Background

Biochemical and physical characteristics of extracellular environment play a key role in assisting cell behavior over different molecular pathways. In this study, we investigated how the presence of chemical binding sites, the pore network and the stiffness of designed scaffolds affected prostate cancer cells.
Methods

A blend of poly hydroxyethyl methacrylate–alginate–gelatin scaffold was synthesized by cryogelation process using polyethyleneglycol diacrylate (PEGda) and glutaraldehyde as cross linkers. The chemical and mechanical scaffold properties ... mehr


Zugehörige Institution(en) am KIT Institut für Funktionelle Grenzflächen (IFG)
Institut für Mikrostrukturtechnik (IMT)
Publikationstyp Zeitschriftenaufsatz
Jahr 2016
Sprache Englisch
Identifikator DOI: 10.1186/s40064-016-2629-z
ISSN: 2193-1801
URN: urn:nbn:de:swb:90-577168
KITopen ID: 1000057716
HGF-Programm 47.02.07; LK 01
Erschienen in SpringerPlus
Band 5
Heft 1
Seiten 902
Lizenz CC BY 4.0: Creative Commons Namensnennung 4.0 International
Bemerkung zur Veröffentlichung Gefördert durch den KIT-Publikationsfonds
Schlagworte Cryogel, Stiffness, Porosity, 3D cell culture, Prostate cancer, Androgen receptor (AR) localization
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