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Detection of post-therapeutic effects in breast carcinoma using hard X-Ray index of refraction computed tomography - A feasibility study

Grandl, S.; Sztrókay-Gaul, A.; Mittone, A.; Gasilov, S.; Brun, E.; Bravin, A.; Mayr, D.; Auweter, S. D.; Hellerhoff, K.; Reiser, M.; Coan, P.

Abstract (englisch):

Neoadjuvant chemotherapy is the state-of-the-art treatment in advanced breast cancer. A correct visualization of the post-therapeutic tumor size is of high prognostic relevance. X-ray phase-contrast computed tomography (PC-CT) has been shown to provide improved soft-tissue contrast at a resolution formerly restricted to histopathology, at low doses. This study aimed at assessing ex-vivo the potential use of PC-CT for visualizing the effects of neoadjuvant chemotherapy on breast carcinoma.

Materials and Methods

The analysis was performed on two ex-vivo formalin-fixed mastectomy samples containing an invasive carcinoma removed from two patients treated with neoadjuvant chemotherapy. Images were matched with corresponding histological slices. The visibility of typical post-therapeutic tissue changes was assessed and compared to results obtained with conventional clinical imaging modalities.


PC-CT depicted the different tissue types with an excellent correlation to histopathology. Post-therapeutic tissue changes were correctly visualized and the residual tumor mass could be detected. PC-CT outperformed clinical imaging modalities in the detection of chemotherapy-induced tissue alterations including post-therapeutic tumor size.
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Volltext §
DOI: 10.5445/IR/1000057882
DOI: 10.1371/journal.pone.0158306
Zitationen: 2
Web of Science
Zitationen: 2
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Photonenforschung und Synchrotronstrahlung (IPS)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2016
Sprache Englisch
Identifikator ISSN: 1932-6203
KITopen-ID: 1000057882
HGF-Programm 56.03.30 (POF III, LK 01)
Soft Matter, Health and Life Sciences
Erschienen in PLoS one
Band 11
Heft 6
Seiten e0158306
Nachgewiesen in Scopus
Web of Science
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