KIT | KIT-Bibliothek | Impressum

Novel roles for well-known players: from tobacco mosaic virus pests to enzymatically active assemblies

Koch, Claudia; Eber, Fabian J.; Azucena, Carlos; Förste, Alexander; Walheim, Stefan; Schimmel, Thomas; Bittner, Alexander M.; Jeske, Holger; Gliemann, Hartmut; Eiben, Sabine; Geiger, Fania C.; Wege, Christina

Abstract (englisch):
The rod-shaped nanoparticles of the widespread plant pathogen tobacco mosaic virus (TMV) have been a matter of intense debates and cutting-edge research for more than a hundred years. During the late 19th century, their behavior in filtration tests applied to the agent causing the 'plant mosaic disease' eventually led to the discrimination of viruses from bacteria. Thereafter, they promoted the development of biophysical cornerstone techniques such as electron microscopy and ultracentrifugation. Since the 1950s, the robust, helically arranged nucleoprotein complexes consisting of a single RNA and more than 2100 identical coat protein subunits have enabled molecular studies which have pioneered the understanding of viral replication and self-assembly, and elucidated major aspects of virus–host interplay, which can lead to agronomically relevant diseases. However, during the last decades, TMV has acquired a new reputation as a well-defined high-yield nanotemplate with multivalent protein surfaces, allowing for an ordered high-density presentation of multiple active molecules or synthetic compounds. Amino acid side chains exposed on th ... mehr

Zugehörige Institution(en) am KIT Center for Functional Nanostructures (CFN)
Institut für Angewandte Physik (APH)
Institut für Funktionelle Grenzflächen (IFG)
Institut für Nanotechnologie (INT)
Publikationstyp Zeitschriftenaufsatz
Jahr 2016
Sprache Englisch
Identifikator DOI: 10.3762/bjnano.7.54
ISSN: 2190-4286
URN: urn:nbn:de:swb:90-587930
KITopen ID: 1000058793
HGF-Programm 43.22.01; LK 01
Erschienen in Beilstein journal of nanotechnology
Band 7
Seiten 613-629
Schlagworte biotemplate; enzyme biosensor; nanotechnology; tobacco mosaic virus; virus-like particles
KIT – Die Forschungsuniversität in der Helmholtz-Gemeinschaft KITopen Landing Page