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Selective Functionalization of Microstructured Surfaces by Laser-Assisted Particle Transfer

Bojnicic-Kninski, Clemens von; Bykovskaya, Valentina; Maerkle, Frieder; Popov, Roman; Palermo, Andrea; Mattes, Daniela S.; Weber, Laura K.; Ridder, Barbara; Foertsch, Tobias C.; Welle, Alexander; Loeffler, Felix F.; Breitling, Frank; Nesterov-Mueller, Alexander

Abstract:
Microcavity arrays represent millions of different reaction compartments to screen for e.g. molecular interactions, exogenous factors for cells or enzymatic activity. We present a novel method to selectively synthesize different compounds in arrays of microcavities with up to 1,000,000 cavities per cm2. In our approach, polymer microparticles with embedded pre-activated monomers are selectively transferred into microcavities with laser radiation. After particle patterning, heating of the particle matrix simultaneously leads to diffusion and coupling of the monomers inside each microcavity separately. This method exhibits flexibility, not only in the choice of compounds, but also in the choice of particle matrix material, which determines the chemical reaction environment. The laser-assisted selective functionalization of microcavities can be easily combined with the intensively growing number of laser applications for patterning of molecules and cells, which is useful for the development of novel biological assays.


Zugehörige Institution(en) am KIT Institut für Funktionelle Grenzflächen (IFG)
Institut für Mikrostrukturtechnik (IMT)
Karlsruhe Nano Micro Facility (KNMF)
Publikationstyp Zeitschriftenaufsatz
Jahr 2016
Sprache Englisch
Identifikator DOI: 10.1002/adfm.201603299
ISSN: 1616-301X
URN: urn:nbn:de:swb:90-597251
KITopen ID: 1000059725
HGF-Programm 47.01.03; LK 01
Erschienen in Advanced functional materials
Band 26
Heft 39
Seiten 7067–7073
Embargofrist Die Publikation ist in KITopen am 09.09.2017 als Volltext frei zugänglich (Open Access).
Schlagworte laser, microstructures, functional microparticles, functionalization, solid phase synthesis
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