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Selective Functionalization of Microstructured Surfaces by Laser-Assisted Particle Transfer

Bojnicic-Kninski, Clemens von; Bykovskaya, Valentina; Maerkle, Frieder; Popov, Roman; Palermo, Andrea; Mattes, Daniela S.; Weber, Laura K.; Ridder, Barbara; Foertsch, Tobias C.; Welle, Alexander; Loeffler, Felix F.; Breitling, Frank; Nesterov-Mueller, Alexander

Microcavity arrays represent millions of different reaction compartments to screen for e.g. molecular interactions, exogenous factors for cells or enzymatic activity. We present a novel method to selectively synthesize different compounds in arrays of microcavities with up to 1,000,000 cavities per cm2. In our approach, polymer microparticles with embedded pre-activated monomers are selectively transferred into microcavities with laser radiation. After particle patterning, heating of the particle matrix simultaneously leads to diffusion and coupling of the monomers inside each microcavity separately. This method exhibits flexibility, not only in the choice of compounds, but also in the choice of particle matrix material, which determines the chemical reaction environment. The laser-assisted selective functionalization of microcavities can be easily combined with the intensively growing number of laser applications for patterning of molecules and cells, which is useful for the development of novel biological assays.

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Volltext §
DOI: 10.5445/IR/1000059725
Veröffentlicht am 10.09.2017
DOI: 10.1002/adfm.201603299
Zitationen: 5
Web of Science
Zitationen: 4
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Mikrostrukturtechnik (IMT)
Institut für Funktionelle Grenzflächen (IFG)
Karlsruhe Nano Micro Facility (KNMF)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2016
Sprache Englisch
Identifikator ISSN: 1616-301X
KITopen-ID: 1000059725
HGF-Programm 47.01.03 (POF III, LK 01)
Biol.Netzwerke u.Synth.Regulat. IMT
Erschienen in Advanced functional materials
Band 26
Heft 39
Seiten 7067–7073
Schlagwörter laser, microstructures, functional microparticles, functionalization, solid phase synthesis
Nachgewiesen in Web of Science
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