Increasing globalization drives companies to produce in global networks, where each site acts autonomously according to its individual target system, influenced by specific location factors or its defined specialization. Despite distributed value creation processes, the overall production quality must be ensured. Hence, a simulation-based approach is presented, which allows for designing an optimal across-site quality control strategy by evaluating different quality measures depending on individual target systems of different sites. At first, a categorization of quality measures and an applicable target system model are presented. Secondly, a simulation approach is described to evaluate implemented measures according to defined performance indicators.