KIT | KIT-Bibliothek | Impressum | Datenschutz

Therapeutic Potential of Gramicidin S in the Treatment of Root Canal Infections

Berditsch, M. 1; Lux, Hannah 1; Babii, Oleg 1; Afonin, Sergii 2; Ulrich, Anne S. 1,2
1 Institut für Organische Chemie (IOC), Karlsruher Institut für Technologie (KIT)
2 Institut für Biologische Grenzflächen (IBG), Karlsruher Institut für Technologie (KIT)


An intrinsic clindamycin-resistant Enterococcus faecalis, the most common single species
present in teeth after failed root canal therapy, often possesses acquired tetracycline resistance.
In these cases, root canal infections are commonly treated with Ledermix® paste, which contains
demeclocycline, or the new alternative endodontic paste Odontopaste, which contains clindamycin;
however, these treatments are often ineffective. We studied the killing activity of the cyclic
antimicrobial peptide gramicidin S (GS) against planktonic and biofilm cells of tetracycline-resistant
clinical isolates of E. faecalis. The high therapeutic potential of GS for the topical treatment
of problematic teeth is based on the rapid bactericidal effect toward the biofilm-forming,
tetracycline-resistant E. faecalis. GS reduces the cell number of planktonic cells within 20–40 min
at a concentration of 40–80 μg/mL. It kills the cells of pre-grown biofilms at concentrations of
100–200 μg/mL, such that no re-growth is possible. The translocation of the peptide into the cell
interior and its complexation with intracellular nucleotides, including the alarmon ppGpp, can explain
... mehr

Volltext §
DOI: 10.5445/IR/1000060509
DOI: 10.3390/ph9030056
Zitationen: 25
Zitationen: 29
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biologische Grenzflächen (IBG)
Institut für Organische Chemie (IOC)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2016
Sprache Englisch
Identifikator ISSN: 1424-8247
KITopen-ID: 1000060509
HGF-Programm 47.02.02 (POF III, LK 01) Zellpopul.auf Biofunk.Oberflächen IBG-2
Erschienen in Pharmaceuticals
Verlag MDPI
Band 9
Heft 3
Seiten Art.Nr.: 56
Vorab online veröffentlicht am 07.09.2016
Nachgewiesen in Scopus
KIT – Die Forschungsuniversität in der Helmholtz-Gemeinschaft
KITopen Landing Page