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Cohort profile: cholangiocarcinoma screening and care program (CASCAP)

Khuntikeo, Narong; Chamadol, Nittaya; Yongvanit, Puangrat; Loilome, Watcharin; Namwat, Nisana; Sithithaworn, Paiboon; Andrews, Ross H.; Petney, Trevor N.; Promthet, Supannee; Thinkhamrop, Kavin; Tawarungruang, Chaiwat; Thinkhamrop, Bandit

Background: Cholangiocarcinoma (CCA) is an extremely aggressive cancer that is usually fatal. Although globally morbidity and mortality are increasing, knowledge of the disease remains limited. The Mekong region of Southeast Asia, and particularly the northeast of Thailand, has by far the highest incidence of CCA worldwide with 135.4 per 100,000 among males and 43.0 per 100,000 among females being reported in Khon Kaen Province. Most patients are first seen during late stage disease with 5-year survival being less than 10 %. Starting in 1984, control and prevention strategies have been focused on health education. Although early detection can substantially increase 5-year survival, there are currently no strategies to increase early diagnosis.
Methods/design: The Cholangiocarcinoma Screening and Care Program (CASCAP) is a prospective cohort study comprising two cohorts- the screening and the patient cohorts. For the screening cohort, ultrasound examination will be carried out regularly at least annually to determine whether there is current bile duct and/or liver pathology so that the optimal screening program for early diagnosis can be established. ... mehr

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DOI: 10.5445/IR/1000063212
DOI: 10.1186/s12885-015-1475-7
Zitationen: 59
Web of Science
Zitationen: 47
Zitationen: 54
Cover der Publikation
Zugehörige Institution(en) am KIT Zoologisches Institut (ZOO)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2015
Sprache Englisch
Identifikator ISSN: 1471-2407
KITopen-ID: 1000063212
Erschienen in BMC cancer
Verlag BioMed Central (BMC)
Band 15
Heft 1
Seiten Art. Nr.: 459
Schlagwörter Bile duct cancer, Cholangiocarcinoma, Cancer screening, Cancer registry, Cohort study
Nachgewiesen in Dimensions
Web of Science
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