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Neuronal Flt1 controls spinal cord vascularization involving venous endothelium with high angiogenic potential

Wild, Raphael

Abstract: Formation of organ-specific vasculatures requires cross-talk between developing tissue and specialized endothelial cells. Here we show how developing spinal cord neurons coordinate vessel growth through balancing of neuron-derived Vegfaa, with neuronal sFlt1 restricting Vegfaa-Kdrl mediated angiogenesis at the neurovascular interface. Our data suggest that spinal cord vascularization proceeds from veins involving two-tiered regulation of neuronal sFlt1 and Vegfaa via a novel sprouting mode.


Zugehörige Institution(en) am KIT Zoologisches Institut (ZOO)
Publikationstyp Hochschulschrift
Jahr 2016
Sprache Englisch
Identifikator DOI(KIT): 10.5445/IR/1000063284
URN: urn:nbn:de:swb:90-632844
KITopen ID: 1000063284
Verlag Karlsruhe
Umfang 139 S.
Abschlussart Dissertation
Fakultät Fakultät für Chemie und Biowissenschaften (CHEM-BIO)
Institut Zoologisches Institut (ZOO)
Prüfungsdaten 21.10.2016
Referent/Betreuer Prof. F. le Noble
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