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Coding and decoding libraries of sequence-defined functional copolymers synthesized via photoligation

Zydziak, Nicolas 1,2; Konrad, Waldemar 1,2; Feist, Florian ORCID iD icon 1,2; Afonin, Sergii 1; Weidner, Steffen; Barner-Kowollik, Christopher 1,2
1 Institut für Biologische Grenzflächen (IBG), Karlsruher Institut für Technologie (KIT)
2 Institut für Technische Chemie und Polymerchemie (ITCP), Karlsruher Institut für Technologie (KIT)

Abstract (englisch):

Designing artificial macromolecules with absolute sequence order represents a considerable challenge. Here we report an advanced light-induced avenue to monodisperse sequence-defined functional linear macromolecules up to decamers via a unique photochemical approach. The versatility of the synthetic strategy—combining sequential and modular concepts—enables the synthesis of perfect macromolecules varying in chemical constitution and topology. Specific functions are placed at arbitrary positions along the chain via the successive addition of monomer units and blocks, leading to a library of functional homopolymers, alternating copolymers and block copolymers. The in-depth characterization of each sequence-defined chain confirms the precision nature of the macromolecules. Decoding of the functional information contained in the molecular structure is achieved via tandem mass spectrometry without recourse to their synthetic history, showing that the sequence information can be read. We submit that the presented photochemical strategy is a viable and advanced concept for coding individual monomer units along a macromolecular chain.

Volltext §
DOI: 10.5445/IR/1000063660
DOI: 10.1038/ncomms13672
Zitationen: 95
Zitationen: 114
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biologische Grenzflächen (IBG)
Institut für Technische Chemie und Polymerchemie (ITCP)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2016
Sprache Englisch
Identifikator ISSN: 2041-1723
KITopen-ID: 1000063660
HGF-Programm 47.02.03 (POF III, LK 01) Zellpopul.auf Biofunk.Oberflächen IBG-3
Erschienen in Nature Communications
Verlag Nature Research
Band 7
Seiten 13672
Bemerkung zur Veröffentlichung Gefördert durch den KIT-Publikationsfonds
Vorab online veröffentlicht am 30.11.2016
Schlagwörter Photochemistry; Polymer synthesis; Polymers
Nachgewiesen in Scopus
Web of Science
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