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Processing and Formulation of Concentrated Protein Solutions - Strategies for their Characterization and Stabilization

Bauer, Katharina Christin

Abstract: Biopharmaceutics are used for therapy of human diseases. Requiring high purity, their downstream process consists of several orthogonal process steps to remove contaminants. Due to increasing product concentrations, these process units are increasingly confronted to cope with concentrated protein solutions. This work describes strategies to characterize protein interactions, aggregation, and dynamic viscosity of concentrated protein solutions in order to improve their processing and formulation.


Zugehörige Institution(en) am KIT Institut für Bio- und Lebensmitteltechnik (BLT)
Publikationstyp Hochschulschrift
Jahr 2016
Sprache Englisch
Identifikator DOI(KIT): 10.5445/IR/1000064829
URN: urn:nbn:de:swb:90-648294
KITopen ID: 1000064829
Verlag Karlsruhe
Umfang IV, 194 S.
Abschlussart Dissertation
Fakultät Fakultät für Chemieingenieurwesen und Verfahrenstechnik (CIW)
Institut Institut für Bio- und Lebensmitteltechnik (BLT)
Prüfungsdaten 14.12.2016
Referent/Betreuer Prof. J. Hubbuch
Schlagworte concentrated protein solutions, formulation, aggregation, dynamic viscosity, protein interactions
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