Processing and Formulation of Concentrated Protein Solutions - Strategies for their Characterization and Stabilization
Abstract:
Biopharmaceutics are used for therapy of human diseases. Requiring high purity, their downstream process consists of several orthogonal process steps to remove contaminants. Due to increasing product concentrations, these process units are increasingly confronted to cope with concentrated protein solutions. This work describes strategies to characterize protein interactions, aggregation, and dynamic viscosity of concentrated protein solutions in order to improve their processing and formulation.
| Zugehörige Institution(en) am KIT | Institut für Bio- und Lebensmitteltechnik (BLT) |
| Publikationstyp | Hochschulschrift |
| Publikationsjahr | 2016 |
| Sprache | Englisch |
| Identifikator | urn:nbn:de:swb:90-648294 KITopen-ID: 1000064829 |
| Verlag | Karlsruher Institut für Technologie (KIT) |
| Umfang | IV, 194 S. |
| Art der Arbeit | Dissertation |
| Fakultät | Fakultät für Chemieingenieurwesen und Verfahrenstechnik (CIW) |
| Institut | Institut für Bio- und Lebensmitteltechnik (BLT) |
| Prüfungsdaten | 14.12.2016 |
| Schlagwörter | concentrated protein solutions, formulation, aggregation, dynamic viscosity, protein interactions |
| Referent/Betreuer | Hubbuch, J. |