A multilevel study of platelet activation at biomaterial surface: from evaluatinhg to controlling hemocompatibility

CVD are the major cause of death world-wide. Their management relies on artificial materials in implants and external devices. They cause thrombotic and inflammatory complications and require therapies that are costly and dangerous for the patient. The research into blood-material interactions failed to find hemocompatible materials, an adequate in vitro test for evaluating hemocompatibility, or appreciate the complexity of the blood-biomaterial interactions.